Oral Vitamin D3 for Treatment of Nutritional Rickets: A Randomized Controlled Trial
نویسنده
چکیده
prevalence of hypovitaminosis D and nutritional rickets [1-3]. Treatment includes therapeutic doses of vitamin D and calcium. In USA, Australia, and UK, the recommended dose and duration of vitamin D therapy is variable with either a high dose bolus therapy (Stoss therapy 200,000-600,000 IU of vitamin D as a single oral or parenteral dose or intermittent high doses) or continuous slow supplementation [4-6]. These recommendations are based on expert opinion and experience rather than sound evidence from randomized comparison of doses. Recent guidelines by Endocrine society recommend 50,000 IU weekly for 6 weeks [7]. Traditionally in India, a single dose of 600,000 IU of vitamin D is used for treating nutritional rickets in children [8]; no national recommendations exist. Recent 300,000 IU or 600,000 IU of Oral Vitamin D3 for Treatment of Nutritional Rickets: A Randomized Controlled Trial
منابع مشابه
A Randomized controlled trial on safety and efficacy of single intramuscular versus staggered oral dose of 600 000IU Vitamin D in treatment of nutritional rickets.
OBJECTIVE Comparison of efficacy and safety of two different regimens of vitamin D-600 000 IU as a single intramuscular dose, and 60 000IU orally once a week for 10 weeks-in treatment of nutritional rickets. METHODS Children with nutritional rickets (age: 0.5-5 years, n = 61) were randomized to receive either 60 000IU vitamin D orally once a week for 10 weeks or 600 000IU single intramuscular...
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UNLABELLED BACKGROUND Vitamin D deficiency is associated with multiple adverse health outcomes including increased morbidity and mortality in the general population and in critically ill patients. However, no randomized controlled trial has evaluated so far whether treatment with sufficiently large doses of vitamin D can improve clinical outcome of patients in an intensive care setting. ME...
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